Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case.
Asumă-ți să fii sănătos prevenția cancerelor digestive
Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only familial cancer features few polyps and a thyroid nodule.
After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease.
Căutarea unei boli la o persoană fără simptome se numește screening. Scopul screening-ului este de a diagnostica cancerul în stadiu incipient, atunci când șansele de vindecare sunt semnificativ mai mari oferind astfel, familial cancer features șansa la o viață mai lungă și cu o calitate mai mare. Cu toate că schimbarea stilului de viață, cu promovarea celui sănătos, prezintă impact în populația generală, screeningul și-a dovedit eficiența doar pentru unele localizări ale cancerelor sau pentru subgrupuri de pacienți, cu risc mai mare de a dezvolta boala.
Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging. The biopsy identified a papillary thyroid carcinoma.
Case 2: the familial cancer features of the patient 30 years old without known diseases was invited to be assessed for thyroid disease. Ultrasound examination discovered a large nodule with familial cancer features.
Microscopic examination done after total thyroidectomy revealed a cribriform morular variant of papillary thyroid carcinoma, a variant that is known to be associated with FAP. Radioiodine ablation was made followed by suppressive thyroxine treatment. In the second case adenomatous polyposis was not found yet. In our knowledge these are the first cases of familial thyroid papillary carcinomas in our setting.
Familial history allowed an earlier diagnosis and familial cancer features good management of the disease in the second case. Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP and in those with a FAP proband in the family.
Nosé V. Endocr Pathol. Modern Pathology ; SS Cavaco BM. Endocrine-Related Cancer ; Richards ML.
V-ar putea interesa
Thyroid ; Nilbert M, Kristoffersson U, Ericsson M, et al: Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age BMC Med Genet. Orphanet J Rare Dis ; 7. Histopathology ; Asian J Surg. Clin Gastroenterol Hepatol.
Clin Colorectal Cancer ; 11 4 : Head Neck ; Ann Surg. Kameyama K, Takami H. Fam Cancer.
Lee S, Hong SW, Shin Familial cancer features al: Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of the literature. Endocr J. Am J Otolaryngol. Cetta F.
Я вас знаю. На такой риск вы не пойдете. Сьюзан было запротестовала, но Стратмор не дал ей говорить. - Вы меня не знаете, молодой человек. Я рисковал всю свою жизнь.
Acta Cytol. Kurihara K, Shimizu S, Chong J, et al: Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma. Jpn J Cancer Res. Ito Y, Miyauchi A, Ishikawa H, et al: Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features familial cancer features FAP-associated and sporadic patients.
Mc Donald TJ.
FAMILIAL SYNDROMIC PAPILLARY THYROID CARCINOMA - REPORT OF TWO CASES
Journal of Oncology. Nasr MR. Modern Pathology.