In this study, our propose was to evaluate the histopatological changes corellated with immunohistochemical results demonstrating the types of cellular infiltration and proliferative activity of gastric mucosa infected with H. Material and method: Gastric endoscopic examinations was performed in patients with anti-H.
Snippets harvested endobiopsic stomach were fixed in formalin and processed by paraffine inclusion. Histological sections were stained with hematoxylin-eosine and Giemsa.
In 65 cases of endobiopsic fragments 36 deep chronic gastritis with intestinal metaplasia, glandular atrophy and intraepithelial neoplasia and 29 gastric cancer kinds immunohistochemical reactions were performed by applying reagents for evidence of H. Results: Endobiopsic specimen found in all H. Histologically, were diagnosed: superficial and deep chronic gastritis associated with premalignant lesions, 29 carcinomas, 2 non-Hodgkins lymphoma and an adematous polyp.
Immunohistochemically, inflammatory infiltrate consisted of numerous T lymphocytes, macrophages and gastric cancer kinds follicles. Foveolar cell nuclei, in areas of intraepithelial neoplasia and carcinomatous cells were intensely stained with Ki, demonstranting increased proliferation. Conclusions: In gastric infection with H. Ki was absent or minimal in chronic gastritis, while in areas of intraepithelial neoplasia was positive in both foveolar and coating epithelium.
Medical eradication of bacteria may cancel inflammatory changes, metaplasia and proliferation of gastric mucosa and thus it prevents the cascade of carcinogenesis.