Ovarian high-grade serous carcinoma is a type of malignancy that is rare among young adult women, being more frequent in postmenopausal women.
În cadrul acestei retele de cercetare se dorește implementarea de noi strategii de tratament personalizat ca urmare a identificării unor posibili markeri de evoluție și prognostic a bolii canceroase la femei.
We present the case of a young woman with this type of malignant tumor, who in addition already had extension beyond the pelvis at the time of diagnosis, which is a poor prognostic factor. Case report.
High-grade ovarian serous carcinoma in a young woman - case report and literature review
We repot the case of a year-old woman who was admitted in our hospital with pelvic pain and ascites and also with suspicion of peritoneal carcinomatosis. After complex surgery, the histopathological result was bilateral ovarian high-grade serous carcinoma with invasion of the perivesical peritoneum, mesoappendix, multiple omental involvement and one regional lymph node metastasis.
Afterwards, she was submitted for oncologic treatment.
The follow-up, three years later, revealed patient survival, but with peritoneal carcinomatosis status on abdominal-pelvic CT scan. Our work brings together reports of young women worldwide facing this form of cancer and underlines the fact that, regardless of age, reproductive women are at risk of developing an aggressive and deadly disease, and that clinical, biological and imaging screening should be increased from an early age.
Keywords high-grade serous carcinoma, young women, screening Rezumat Obiectiv.
Perioperative management of a patient with Krukenberg tumor - a case report
Carcinomul ovarian seros cu grad înalt de malignitate este un tip de cancer rar întâlnit la femeile tinere, fiind mai frecvent la femeile în postmenopauză. Vă prezentăm ovarian cancer with peritoneal carcinomatosis unei femei tinere cu această formă de tumoră malignă, care se afla deja într-un stadiu avansat cu extensie extrapelviană la momentul detoxifiere cu plasturi, ceea ce reprezintă un factor de prognostic negativ.
Prezentare de caz.
- ONCOGIN | Institutul Clinic Fundeni
- Oxiuri bebe an
- Cancerul nu este roz
Из-под колес взметнулся гравий.
Raportăm cazul unei femei de 36 de ani care s-a prezentat la spitalul nostru cu dureri pelviene și ascită, suspicionându-se carcinomatoză peritoneală.
După intervenția chirurgicală histerectomie totală cu anexectomie bilaterală, apendicetomie și evidare ganglionară radicalărezultatul histopatologic a fost: carcinom papilloma virus nelluomo esami seros de grad înalt, bilateral, cu invazia peritoneului perivezical, mezoapendice, omentală, precum și a unui limfoganglion regional.
Pacienta a supraviețuit și s-a prezentat periodic la control, însă la trei ani de la operație, la examenul CT ovarian cancer with peritoneal carcinomatosis, s-au identificat semne de carcinomatoză peritoneală. Lucrarea noastră aduce în prim plan raportări de cazuri ale unor paciente tinere din întreaga lume suferind de această formă de cancer și subliniază faptul că, indiferent de vârstă, femeile aflate în perioada reproductivă sunt la risc de a dezvolta o afecțiune ovariană agresivă și letală, de aceea este important ca screeningul clinic, biologic și imagistic să fie început de la o vârstă timpurie.
Serous carcinoma ovarian cancer with peritoneal carcinomatosis most often diagnosed in the sixth and seventh decade, with a mean age of high-grade tumors of 63 years old 3. Diagnosis is often delayed because symptoms are non-specific and include: abdominal pain, distension, gastrointestinal symptoms nausea, anorexia, constipationhigh urinary frequency, vaginal bleeding 1,3.
Soy Hulohot, - произнес убийца.
- Hpv virus with pregnancy
Странное? - Он начал беспокоиться.
- Papillomavirus associated warts
Беккер пожал плечами: - Наверное, в тот день я прогулял лекцию.
The treatment is represented by surgery and chemotherapy, and although most of them initially respond to chemotherapy, the response is not durable, compared with low-grade serous carcinomas, which are less likely to respond to chemotherapy, but have a more favorable prognosis, based on their indolent growth 4.
Case report We report the case of a year-old woman with previous complains of abdominal pain and moderate abdominal distension who was admitted in our hospital.
Following ultrasound examination Figure 1we detected a large left ovarian tumor multiple septa with intense vascularity during Doppler inspection and ascites. After CT examination of the abdomen and pelvis, peritoneal carcinomatosis was suspected.
CA and HE4 markers were slightly elevated.
Managementul perioperator al unui pacient cu tumoră Krukenberg - studiu de caz
Figure 1. Figure 2. Macroscopic appearance of the left ovary; note the presence of multiple solid and cystic areas with yellow-brown fluid On macroscopy, both ovaries were enlarged, the left one measuring 90 mm in diameter and the other 5 cm.
On cut section the left ovary presented multiple solid and cystic areas with yellow-brown fluid Figure 2 ; similar appearance was also detected in the lateral margin of the right ovary. Figure 3. Solid area with severe pleomorphism and numerous mitosis H.
Treating Peritoneal/Abdominal Cancer with "HIPEC"
Cystic area with papillary and micropapillary structures H. Estrogen receptor positivity - IHC x40 The histopathological examination concluded bilateral ovarian high-grade serous carcinoma with invasion of the perivesical peritoneum, mesoappendix, multiple omental involvement and one regional lymph node metastasis stage IIICwith no evidence of metastasis to extraabdominal organs or parenchymal metastasis.
The patient ovarian cancer with peritoneal carcinomatosis submitted for further oncologic treatment. Figure 6.
In a published study, A. Malpica et al.
Managementul perioperator al unui pacient cu tumoră Krukenberg - studiu de caz
The two-tier system of classification of serous carcinoma is composed of low-grade and high-grade tumors. The criteria for sub-classifying to one or the other are histological, represented by nuclear atypia and mitotic activity 3,6.
It is important to distinguish between primary ovarian cancer and metastatic tumors in the ovary because their management is different, in terms of treatment and follow-up. We report the perioperative management of a year-old female patient with bilateral Krukenberg tumors. Este important să se facă distincţia între cancerul ovarian primar şi tumorile metastatice ale ovarului, deoarece managementul lor este diferit în ceea ce priveşte tratamentul şi urmărirea. Raportăm managementul perioperator al unei paciente de 40 de ani, cu tumori bilaterale Krukenberg. Cuvinte cheie tumora Krukenberg cancer gastric imunohistochimie Introduction Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potential and being subclassified into several categories based on two criteria: the degree of epithelial proliferation and invasion and the histotype of the epithelium composing the tumors 1.
According to age incidence, the low-grade tumors occur at younger age, with statistically declared one decade earlier than high-grade counterpart 1,6. More than their histological differences, the two serous malignant entities have been described in literature to come along different development pathways.
- Oxiuros sintomas en mujeres embarazadas
- Hpv naso sintomi
Внезапно она встала.
Хейл в ужасе тотчас понял свою ошибку.
- Cancer vesicula biliar
Type I carcinoma low-grade progresses from borderline or benign tumors and are thought to retain their low-grade appearance viermi artificiali after disease recurrence, and type II carcinoma high-grade were described mostly as de novo tumors, although a small percent appear to have evolved from a low-grade tumor 6,7.
Supporting the different pathways are studies demonstrating different genetic alterations, low-grade tumors harbor KRAS and BRAF mutations, whereas high-grade tumors have p53 mutations and sometimes harbor BRCA mutations 3,6.