Helminth therapy and microbiome

helminth therapy and microbiome
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Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system.

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The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine. Such a strategy is exemplified by vaccination, with pathogen molecules employed to induce protective immunity against the given or related species of pathogen.

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The following chapters explore the concept of using pathogen-derived helminth therapy and microbiome modulating molecules as a therapy. In doing so, they may provide the drug cabinet of the future for treating a spectrum of unrelated disease. Herein, a range of immune modulating molecules or strategies from various pathogens is examined in one volume. The intention of the book was to have chapters addressing immunomodulating molecules from different pathogens.

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The range of pathogens considered includes bacteria chapters by Williams, van Strijp and Rooijakkersviruses chapters by Bowie, McFaddenprotozoan parasites Alibertihelminths Harnett, Fallonfungi Sorrell and parasitic ticks Anguita.

Chapters also address specific immunomodulatory molecules or strategies.

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While Elliott and Weinstock have contributed a provocative chapter exploring the use of live parasitic helminth infections as a therapeutic strategy for immune-mediated diseases; indeed trials have already been completed for such an approach. With respect to pathogens usurping an immune pathway, Alcami and colleagues here reviewed the growing number of pathogens that have evolved a range of molecules that can modify many aspects of the chemokine system.

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This book is timely due to the need to expand the horizons of conventional drug discovery. A trend in the biopharmaceutical pipeline of fewer drugs to market is illustrated by USA FDA in approving the lowest number of new molecular entities since As the drug discovery and development industry broadens its search for new drugs to less traditional strategies, this book will be a reference to helminth therapy and microbiome potential helminth therapy and microbiome exploiting pathogen as a source of the anti-inflammatory drugs of the future.

Finally, this book whets the appetite for the reader, whether in academia or industry, to explore opportunities for exploiting pathogens for the discovery of new processes in immunobiology and, ultimately, for development of new therapies for human inflammatory diseases.