Anca Zgură, Laurenţia Galeş, Prof. Breast, ovarian, cancer colon incidence cervical cancer are the most common cancers diagnosed during pregnancy. The manifestations encountered in cancer colon incidence cancer, such as abdominal pain, constipation, vomiting, nausea, rectal bleeding and altered bowel movements, are also found in normal pregnancy.
In this paper, we present a case of colorectal cancer with hepatic metastasis diagnosed in a year-old preganant woman IIG, 1Pat 32 weeks of pregnancy.
Keywords pregnancy, colorectal cancer, metastasis, teratogencity, chemotherapy Rezumat Incidenţa cancerului colorectal în timpul sarcinii este mică, de un caz la 1. Cancerul mamar, ovarian şi cel cervical sunt cele mai frecvente tipuri de cancer diagnosticate în timpul sarcinii.
Manifestările întâlnite în cancerul colorectal, precum dureri abdominale, constipaţie, vărsături, greaţă, sângerări rectale şi tulburări intestinale, se întâlnesc şi în timpul sarcinii normale, făcând dificilă diagnosticarea pe parcursul sarcinii. În această lucrare vă prezentăm cazul unei paciente de 36 de ani IIG, 1Pîn săptămâna a a de sarcină, diagnosticată cu cancer colorectal, prezentând şi metastaze hepatice.
Cuvinte cheie cancer colorectal metastaze teratogenitate chimioterapie Introduction Cancer colon incidence incidence of colorectal cancer during pregnancy is reduced, being estimated at approximately one in every preganancies Breast, ovarian and cervical cancer are the most common cancers diagnosed during pregnancy 2.
The manifestations encountered in colorectal cancer, such as abdominal pain, constipation, vomiting, nausea, virus del papiloma en manos bleeding and altered bowel movements, are also found cancer colon incidence normal pregnancy 5.
Most of the colorectal cancers are missed and are diagnosed in advanced stages. Using the antineoplastic agents in a pregnant patient is a difficult decision, with cancer colon incidence of safety and efficacy implications 6.
The treatment plan depends on the desire of the pregnant woman, the stage of the disease, the possible teratogenic effects of the antineoplastic agents and abortion We present in this paper a case of colorectal cancer with hepatic metastasis diagnosed in a patient at 32 weeks of pregnancy. Figure 1.
University of Texas M. Anderson Cancer Center Summary: Over the next 20 years, the number of new cancer cases diagnosed annually in the United States will increase by 45 percent, from 1. Anderson Cancer Center. It predicts a 67 percent increase in the number of adults ageor-older diagnosed with cancer, from 1 million in to 1.
She also had constipation and anemia. She was initially evaluated by her gynecologist, cancer colon incidence suggested a second opinion from a gastroenterologist, who performed an abdominal and pelvic IRM.
The abdominal and pelvic IRM evaluation revealed global hepatomegaly mm cranio caudal right lobe, 97 mm antero-posterior left lobeand more lobular contour space replacement formation.
The CT scan of the thorax was without secondary pulmonary cancer colon incidence. There was no family history of cancer. The physical examination at the time was unremarkable, except for normal signs of pregnancy. The patient was anemic at the time of presentation, the hemoglobin level was 9. After the imagistic and biological evaluation, she was refered to a surgeon, who thought that her pregnancy would make difficult to receive prompt adjuvant therapy.
The patient was only week pregnant at the time of diagnosis. A caesarean section was performed, resulting in the birth of a premature baby, weighing g, who received an Apgar score of 9.
Colorectal Cancer Screening
During the same operation, a left hemicolectomy and right oophorectomy were also performed. The histopatological raport revealed a moderate adenocarcinoma G2six nodes were examinated, but only two were positive.
Colorectal cancer during pregnancy
Cancer colon incidence histopatological examination of the ovary showed metastasis of moderate adenocarcinoma Krukenberg ovary. Before deciding on the initiation of chemotherapy, the patient experienced altered generalized status, medium cancer colon incidence, pleurisy and gambling edema.
She received a cycle of adjuvant chemotherapy consisting of cetuximab mg. The patient tolerated the hepatic cancer review with supportive treatment and minimal hematologic and non-hematologic toxicities.
Cancerul colorectal în sarcină
After one month, we changed the chemotheray cycle with cetuximab, oxaliplatin and 5-FU, due to cancer colon incidence improvement of the general state.
A follow-up CT scan after three months showed evolution in mild numerical regression of liver lesions. The hepatomegaly was maintained. Fine fluid blade in dimensional regression. Without bone metastases.
The adjuvant chemotherapy combined with targeted therapy using cetuximab has been considered for the patient in order to eradicate the metastatic disease. Discussion Despite the low incidence rate of 0. Colorectal cancer is among the eight most common malignancies in pregnancy 2. Colorectal cancer in pregnancy represents a serious situation, and there are many challenging issues regarding cancer colon incidence diagnosis and management in pregnancy. Because the signs and simptoms are similar in pregnancy and colorectal cancer, the colorectal cancer can be concealed In our patient, the abdominal pain was misdiagnosed as a sign and simptom of a normal pregnancy.
There are limitations and contraindications for using imaging tests during pregnancy. IRM remains relatively safe in pregnancy and the best option to evaluate the colorectal cancer. Serum CEA is an important test used in the evaluation of patients with colorectal cancer CEA levels during pregnancy may be elevated and can be used for monitoring the response of the treatment 15, Due to the fact that colorectal cancer is encoutered in the eldery and rarerly in cancer colon incidence patients, it is assumed that there are a number of predisposing factors, such as Lynch syndrome, Peutz-Jeghers syndrome and inflammatory bowel disease Another challenging issue is the treatment, which should be started as early for the mother, and is based on the gestational age and tumor stage.
If diagnosis occurs during the first trimester of pregnancy, it may be expected until cancer colon incidence fetus becomes viable, but with significant tumor progression 18, If the diagnosis occurs after the 20th week of pregnancy, colon resection may be delayed.
Cancerul colorectal în sarcină
Chemotheray is safer in the second and third trimesters, when organogenesis is complete There are no human data for the effect of cetuximab in pregnancy The ovarian metastatic disease from colorectal cancer colon incidence is another challenge. The incidence of ovarian metastases from colorectal cancer is higher in pregnant women.
The survival of the pregnant woman with ovarian metastases is poor. Nesbitt et al. There are no fetal risk due to the malignancy itself, even in metastasis cases. The pregnant woman with colorectal cancer has a poor prognosis.
A review of 15 cases revealed that all patients with colorectal cancer presented in stage IV, and these patients died in 12 months after delivery Conclusions Colorectal cancer in pregnancy represents a diagnostic and therapeutic challenge.
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Because the signs and simptoms are similar in pregnancy and colorectal cancer, the diagnosis of colorectal cancer is often delayed. The therapeutic decison for a pregnant patient with colorectal cancer should involve a multidisciplinary team, and there must be taken into account the life of the unborn child and the survival of the mother.
Dramatic Growth In Cancer Rates Among US Elderly, Minorities Predicted -- ScienceDaily
Conflict of interests: The authors declare no conflict of interests. Carcinoma of the colon associated with pregnancy: report of a case. Dis Colon Rectum. Colorectal cancer discovered during pregnancy. J Gynecol Obstet et Biol Reprod.
Dramatic Growth In Cancer Rates Among US Elderly, Minorities Predicted
Cancer and pregnancy: an overview for obstetricians and gynecologists. Am J Obstet Gynecol. Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer?