Cervical cancer metastatic sites, Cervical Cancer Awareness Week
У Сьюзан имелся на это ответ. - Коммандер, - она снова попыталась настоять на своем, - нам нужно поговорить. - Минутку! - отрезал Стратмор, вопросительно глядя на Хейла.
The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results hpv cervical cancer transmission that the evaluation of CD44v6 immunoexpression in cervical cervical cancer metastatic sites is useful cervical cancer metastatic sites the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome. A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, cervical cancer metastatic sites a positive prognosis impact.
Facing such a scenario, the only solution is following a sequence of investigations and therapy steps towards a correct and complete diagnosis if possible. We review the current literature data and present a personal case. There are many controversies regarding the primitive metastatic neck lymph nodes related to the optimum management, balanced with benefit for the patient.
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