Ginecologie minim-invaziva 1 Apply Ginecologie minim-invaziva filter HPV și cancerul de col uterin HPV - Human Papilloma Virus — este un virus comun care se transmite prin contact sexual vaginal, oral sau anal. Infecţia persistentă cu HPV reprezintă cauza principală a cancerului de col uterin. Sunt descrise aproape 40 de genotipuri care pot fi localizate hpv cancer risk nivelul organelor genitale atât la bărbat, cât şi la femeie, precum şi în faringe şi cavitatea bucală, determinând infecţii asimptomatice.
About 6 million pa- tients with cancer die every year worldwide. In recent years, the rate of cancer detection has raised up because of progression in diagnostic technologies 1.
Gynecological malignancy involving vaginal cancer is uncommon and the most victims are reported from developing countries 2. There are different risk factors including smoking, poor hygiene, high parity, intimating with several sexual partners, in hpv cancer risk exposed diethylstilbestrol, immu- nodeficiency, genital warts and sexually transmitted Human Papilloma Virus HPV that predispose vaginal cancer.
The condom does not prevent the transmis- sion of HPVs; because the HPVs are able to transmit throughout genital skin to skin contact. The HPV not only in women but also in men may cause genital cancers.
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The virus is ubiquitous and can be isolated from different human races and animals 9. The earlier recognition of vaginal cancer was introduced in by Meigs and Graham.
HPV Causing Cancer In Men
However, the illustration of primary vaginal cancer was achieved by Cruveilhier in 19th century. This type of cancer is often known as the secondary gynecological disease which may occur in the consequence of metastasis from cancerous anus, cervix, colon, endometrium, ovary, rectum and vulva in women.
Thus, the primary hpv cancer risk of vaginal cancer is rare 6,10, There are different types of primary vaginal cancers Table 1 The previous reports show that squamous cell carci- noma ranks as the most prevalent vaginal cancer with the percentage of about The majority of squamous cell carcinoma is in association with HPV 6.
The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular hpv cancer risk like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.
The average age of mortality for patients with vaginal cancer hpv cancer risk recorded about 65 years old 6, There is a direct associa- tion between HPV and cervico-vaginal cancer. In utero contact diethylstilbestrol is the predominant cause of vaginal cancers of melanoma and adenocarcinoma 3,6, HPV family includes more than carcinogenic and non-carcinogenic hpv cancer risk. HPVs have positive tropism to human mucosal and moist membranes and hpv cancer risk.
The low risk carcinogenic types of HPVs are important causative agent for viral warts such as genital warts Table 2 3,9, The aim of this article is to review the subtitle of vaginal cancer staging, epidemiology of HPV vaginal cancers, benign cancer need chemotherapy characteristics and pathogenesis of HPV vaginal cancers, clinical demonstrations of HPV vaginal cancers diagnosis, treatment and prevention.