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Merișescu, S. Schiopu, E. Osman, M. Most pediatric cases are caused by Aspergillus fumigatus. Atopic asthma can be precipitated by inhalation of specific spores, leading to an immediate response by IgE and bronchospasm.
The authors present the case of a child diagnosed with asthma, when an infant, with oscillating evolution. Inflammatory syndrome is strongly positive. Finally, we excluded any autoimmune or choroid plexus papilloma medscape and infectious etiology and we confirmed allergic bronchopulmonary aspergillosis. Keywords: Aspergillosis, asthma Introduction Aspergillosis is one of the most common causes of exacerbation of asthma. Exposure to colonies of Aspergillus has been described as a factor causing numerous respiratory diseases, including asthma, chronic eosinophilic pneumonia, hypersensitivity pneumonia and bronchopulmonary aspergillosis.
Case report We report the case of a 3-year-old girl who was diagnosed with asthma and eczema at 1 year of age.
At onset, the clinical symptoms present an erythematous-maculo-papular eruption, and choroid plexus papilloma medscape. After performing a bone marrow puncture, the evaluation of the bone marrow aspirate smears showed slightly reduced cellularity for the patient s age, a left shift in the granulocyte lineage, normal maturation.
Some cellular elements showed macrocytosis and cytoplasmic vacuoles, mild eosinophilia. Erythropoietic lineage choroid plexus papilloma medscape mild hyperplasia, normoblastic, with normal maturation. The megakaryocytes were in normal percentage in all stages of maturation. After smear examination, we did not find atypical cells. We learned from the patient history about repeated exposure to mold in the family! IgE Aspergillus fumigatus: : 0.
The distribution of total IgE Fig. The distribution of IgE Aspergillus fumigatus Chest X-ray: reticular and micronodular opacities of different size, diffuse contour supra-- para- and infrahilar bilateral.
Fig 4, 5. Radiologic aspect Fig. Radiologic aspect Bronchoscopy: : muco-purulent secretions very abundant coming from all lobar orifices, predominantly right. The cultures were negative for microbial germs, negative for fungi, with rare lysed neutrophils; eosinophils, crystals Charcot were not noticed, AFB absent.
Given the historical data, the high values of total IgE, IgE to aspergillus value, extensive bilateral infiltrates radiological aspect; one can support the diagnosis of allergic bronchopulmonary aspergillosis.
The evolution was slow with progressive diminishing functional respiratory syndrome. Patients with chronic lung disease eg, asthma, cystic fibrosis can retain the secretions aspergillus fumigatus, leading to an immune response that exacerbates choroid plexus choroid plexus papilloma medscape medscape symptoms.
A chronic colonization of mucosal fumigatus produces elevated levels of immunoglobulin G IgG and immunoglobulin E IgEwhich lead to recurrent bronchospasm.
There is a similarity between the clinical manifestations of allergic bronchopulmonary aspergillosis and asthma with fungal sensitization. Luise E.
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Rogg and William J. Chapter Aspergillus.