We also wanted to emphasize that the occurrence of hepatocellular carcinoma HCC is increasingly associated with obesity, metabolic syndrome and nonalcoholic fatty liver disease.
Material and methods: A clinical retrospective study was carried out on a series of 13 patients operated for morbid obesity in our surgical unit.
Included in this study were only the obese patients referred for bariatric surgery without other risk factors for liver disease and in whom a liver biopsy was taken during metabolic surgery. Results: The pathology report revealed different stages of nonalcoholic fatty liver disease in all 13 patients: pathological features of steatohepatitis 7 patientshepatic steatosis 5 patients and lesions specific for evolving cirrhosis 1 patient.
Regardless of the pathological changes of the hepatic cancer risk factors, except the patient with evolving cirrhosis, none of these patients showed changes in classical liver function blood tests.
Discussions: Hepatic alteration in obese patients, ranging from simple steatosis to steatohepatitis or even cirrhosis, is not always correlated with the values of classical biological liver function tests. Literature data suggest the involvement of adipokines in the development and progression of steatosis as the hepatic expression of hepatic cancer risk factors and chronic inflammation syndrome occurring in obese patients.
Furthermore, these proteins secreted by adipose tissue seem to be related to the HCC occurrence. However, none of these studies show the exact pathway cancerul de prostata recidiva by the hepatic cell from simple fatty liver to hepatocellular carcinoma. Conclusions: finding and selecting the population at risk for fatty liver disease progression and for HCC development among obese patients is mandatory.
Physical status: The use and interpretation of anthropometry.
- Papilloma umano cause
- Ciroza la ficatcancer la plamâni, boli de inima
- Cirrhotic liver - Traducere în română - exemple în engleză | Reverso Context
- Hpv uterus removal
- Vaccino papilloma virus dolore al braccio
- [The epidemiological aspects of the relationship between viral hepatitis and primary liver cancer].
Сьюзан рассказала Дэвиду про КОМИ НТ, подразделение глобальной разведки, в распоряжении которого находилось немыслимое количество постов прослушивания, спутников-шпионов и подслушивающих устройств по всему земному шару.
Отпусти ее, - спокойно сказал Стратмор.
State-specific prevalence of obesity among adults--United States, Mob Mortal Wkly Rep. International Agency for Research on Cancer. Estimating the world cancer burden: Globocan Int J Cancer ; Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults.
Aliment Pharmacol Ther. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.
Bellentani S, Tiribelli C. The spectrum of liver disease in the general population: lesson from the Dionysos study. J Hepatol. Nzeako, Z. Goodman, K. Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of North American patients. Am J Clin Pathol, ; 1 Sanyal, A. Poklepovic, E. Moyneur, et al.
Curr Med Res Opin ; 26 9 : NIH conference. Gastrointestinal surgery for severe obesity. Hepatic cancer risk factors Development Conference Panel.
Ann Intern Med. The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease. Hepatol Ann Hepatol ; 7 4 : Relative contribution of iron burden, HFE mutations and insulin resistance to fibrosis in non-alcoholic fatty liver.
Hepatol ; Verdelho Machado, H. Non-alcoholic fatty liver disease: What the clinician needs to know. World J Gastroenterol.
[Nonalcoholic and alcoholic steatohepatitis].
Increased oxidative stress in obesity and its impact on metabolic syn-drome. J Clin Invest. Marra F, Lotersztajn S. Pathophysiology of NASH: perspectives for a targeted treatment. Curr Pharm Des. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steatohepatitis.
Pietrangelo A. Metals, oxidative stress and hepatic fibrogenesis.
Liver disease: cancer screening and treatment at Ohio State
Sem Liv Dis. Beyond hereditary hemochromatosis: new insights into the relationship between iron overload and chronic liver diseases.
Dig Liver Dis ; Involvment and Role of Iron in Nonalcoholic Steatohepatitis. Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. Liver Int.
Masader – Oman Virtual Science Library
Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Leptin regulation of the immune response and the immunode-ficiency of malnutrition.
La Cava A, Matarese G. The weight of leptin in immunity.
In particular, attention is given to the information achieved by experimental models, such as phantoms and animal studies. This review targets the clinical applications of ARFI in the evaluation of chronic diffuse disease, especially of liver and kidneys.
Nat Rev Immunol ; 4: Dietary and genetic obesity promote liver inflammation and tumor-igenesis by enhancing IL-6 and TNF expression.
Transient elastography an alternative to liver biopsy in patients with chronic hepatitis C?