The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between the alterations in Stages of hpv cervical cancer and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.
Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of E-cadherin immunoexpression in tumors with hpv virus eye therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome.
This is cultures, identical cultures, of cervical cancer cells. Acestea sunt două culturi identice de cancer cervical. Propune un exemplu Alte rezultate The Pap Test looks for the abnormal cells that can develop into cervical cancer. Testul Papanicolau examenul citologic urmareste depistarea celuleor anormale care se pot transforma in cancer. Cervical cancer is a disease caused by the uncontrolled multiplication of some cells located at the squamo-columnar junction that become malignant.
A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact. Int J Cancer ; Rom J Morphol Embryol ; CD44 isoform 6 CD44v6 is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma.
Human Papillomavirus - HPV - Nucleus Health
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- cervical cancer cells - Traducere în română - exemple în engleză | Reverso Context
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