Type 1 diabetes previously known as insulin-dependent, juvenile or childhood-onset is characterized by deficient insulin production and requires daily administration of insulin.
Type 1 diabetes T1D is an autoimmune disease where the pancreatic insulin-producing beta cells are destroyed by the immune system.
The increasing incidence of type 1 diabetes T1D and autoimmune diseases in industrialized countries cannot be exclusively explained by genetic factors. Human epidemiological studies and animal experimental data provide accumulating evidence for the role of environmental factors, such as infections, in the regulation of allergy and autoimmune diseases.
The prevalence of type 1 diabetes has been increasing in the developed world but it is uncommon in tropical regions where diseases such as leprosy, leishmania, schistosomiasis and malaria are common. In rodent models of type 1 diabetes infection with virus, bacteria and helminths have been shown to inhibit the development of autoimmunity Conclusion The work explain how S.
Zaccone P1, Cooke A.
DOI: Hall doi: