Methods pancreatic cancer bone metastases technologies based on molecular and cellular medicine applied in surgery and treatment of bone cancer, bone metastases and osteo-articular lesionsOSMOCEL January 10, icia Objectives: the development of new surgical methods pancreatic cancer bone metastases techniques adapted to the needs of bionanostructures with multifunctional properties, obtained by specific methods of molecular or colloidal auto-assembly.
Modalities of treatment include the combination of anti-cancer therapies surgery, radiotherapy and chemotherapy, particularly with cisplatin, 5-fluorouracil, doxorubicin and taxol and of therapies for the regeneration of the bone system, by the use of investigation and interventional techniques and methods based on molecular and cellular medicine.
Since bone represents a typical example of natural nanocomposite, the orthopedic research in this project will develop new strategies regarding the engineering of bone tissue, using nanobiomaterials with controlled structure and properties, which should fit the physical and chemical characteristics of the physiological bone.
Metastatic cancer has spread beyond the pancreas to other parts of the body Metastatic : cancerul s-a extins în afara pancreasului în alte părţi ale organismului Metastatic cancer in the liver originating in other organs cancer metastatic în ficat originare din alte organe It's a stage III metastatic cancer. E în stadiul 3. Cancer metastazat. Docetaxel pharmacokinetics in the presence of prednisone was studied in patients with metastatic prostate cancer.
While these last years some progress has been reported in the field of nanobiotechnology, extensive research at molecular and cellular level is still pancreatic cancer bone metastases in order to understand physical and chemical phenomena characteristic for the interface between physiological bone, nanobiomaterials and surgical implant.
The expected results will lead to the development of new nanobiomaterials and theoretical models in biomechanics and bioinformatics, aimed to support the efforts of developing new surgical techniques, adapted to orthopedic necessities and for a reasonable cost. Fundamental research and deepening of interaction mechanisms for protein, particularly collagen, with the bone matrix, artificially created from nanobiomaterial, with or without surgical implants, is important in this pancreatic cancer bone metastases.
The results of the research will open new strategies to approach and understand the bone cells adhesion for instance osteoblasts — which are the bone forming cells on the artificial bone matrix, an essential problem in the stage of osteosynthesis and integration in the physiological bone system.
The multidisciplinary collaboration organized in the consortium i.
Also it is difficult to make the differential diagnosis with the pseudotumoral chronic pancreatitis, which has similar imagistic and clinical features, so surgery with hystopathologic diagnosis is needed. The preoperative staging of the pancreatic cancer pancreatic cancer bone metastases a limited accuracy max. Up to now, no predictive tumor or host features e. In practice, the hepatic metastases under 1 cm are often unidentified before surgery through conventional imagistic methods, being detected only during surgery or becoming visible during the immediate postsurgical follow-up. New accurate and cost-efficient diagnosis tools are necessary, with role of predictive biomarker for malignancy in doubtful cases or in patients with risk factors diabetes, chronic pancreatitis and useful as a prognostic indicator in cases already diagnosed.
The orthopedic surgeon, the oncologist, the radiation oncologist, the specialist in physical chemistry of the drug and of anti-cancer drug delivery systems, and the bio-computer scientist must all be involved in specific steps of the project, without forgetting the importance of psychotherapy. The objectives of the present project are aimed to the development of new surgical methods and techniques adapted to the needs of bionanostructures with multifunctional properties, obtained by specific methods of molecular or colloidal auto-assembly.
These bionanostructures present a high interest in orthopedic surgery and treatment of both bone cancer and bone metastases, and osteo-articular lesions. The nanobiostructures should contain collagen with or without another polymer, nanostructured hydroxyapatite, anticancer drugs cisplatin, 5-fluorouracil, doxorubicin or taxolbio compounds treatment of enterobiasis pancreatic cancer bone metastases transport, e.
The bionanostructures are selectively and specifically designed and obtained for the treatment of bone affections and in view to bone regeneration They are also destined to improve the cancer therapy and to reduce the secondary effects of anti-cancer compounds.
In order to characterize these bionanostructures, various modern techniques and methodologies are used, e.
Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers.